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Anti-S1P Lyase polyclonal antibody

Cat no: CABT-B1663

Anti-S1P Lyase polyclonal antibody

Rabbit Anti-Human S1P Lyase polyclonal antibody for WB, IHC-P. Sphingosine-1-phosphate lyase 1 (EC 4.1.2.27; UniProt O95470; also known as hSPL, S1P lyase, Sphingosine-1-phosphate aldolase, SPL 1, SP-lyase 1) is a type III single-pass ER membrane protein encoded by the SGPL1 (Also known as S1PL, SPL) gene in human (Gene ID 8879). SP-lyase 1 catalyzes the irreversible retro-aldol cleavage of sphingosine 1-phosphate to 2-hexadecenal and phosphoethanolamine. S1P lyase activity knockout is reported to offer protection in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), by preventing T cell egress from the lymph nodes into central nervous system (CNS). S1P lyase overexpression is also demonstrated to potentiate serum withdrawal-induced apoptosis in HEK293 cultures.

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SPECIFICATIONS

Catalog Number

CABT-B1663

Hosts

Rabbit

Reactivities

Hum

Target

SGPL1

Gene Id

8879

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

SUPPLIER INFO

Creative Diagnostics

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