Rabbit Anti-Human SCN11A polyclonal antibody for ICC/IF, IHC-P, IHC-Fr, WB. Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the;action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and;conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane;localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of;disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6;transmembrane segments and intra- and extracellular linkers.