Anti-SH3BP4 polyclonal antibody

Rabbit Anti-Human SH3BP4 polyclonal antibody for IHC. SH3 domain-binding protein 4, also known as, EH-binding protein 10 or Transferrin receptor-trafficking protein, and encoded by the gene name(s), SH3BP4 or BOG25 or EHB10 or TTP, may function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation; thereby may indirectly regulate cell growth, proliferation and autophagy.

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SPECIFICATIONS

Catalog Number

CABT-B1932

Hosts

Rabbit

Reactivities

Hum

Target

SH3BP4

Gene Id

23677

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20В°C may cause glycerol containing solutions to become frozen during storage.