Anti-SLCO1B3 polyclonal antibody

Rabbit Anti-Human SLCO1B3 polyclonal antibody for IHC, ICC. Solute carrier organic anion transporter family member 1B3, also known as, Liver-specific organic anion transporter 2 (LST-2) or Organic anion transporter 8 or Organic anion-transporting polypeptide 8 (OATP-8) or Solute carrier family 21 member 8, and encoded by the gene name(s), SLCO1B3 or LST2 or OATP1B3 or OATP8 or SLC21A8, is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. SLCO1B3 is highly expressed in liver, in particular, at the basolateral membrane of hepatocytes near the central vein. It is also highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder. Mutations in SLCO1B3 have been associated with Hyperbilirubinemia, Rotor type.

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SPECIFICATIONS

Catalog Number

CABT-B1765

Hosts

Rabbit

Reactivities

Hum

Target

SLCO1B3

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20В°C may cause glycerol containing solutions to become frozen during storage.