Anti-Somatostatin-28 polyclonal antibody

Rabbit anti-Somatostatin-28 polyclonal antibody for IS, WB, RIA. Somatostatin was first characterized as the major physiological inhibitor of growth hormone release (somatotropin) from the pituitary but has subsequently been shown to inhibit the release of many other physiologically important compounds, including insulin, glucagon, gastrin and secretin. It is therefore a major factor in the control of metabolism. It also functions in the central nervous system as a neurotransmitter/neuromodulator in the control of motor activity and cognitive functions; it may be involved in epilepsy and in Alzheimer's disease. This gastrointestinal and hypothalamic peptide hormone is in two forms (14 and 28 residues) and is found in gastric mucosa, pancreatic Islets, nerves of the gastrointestinal tract, posterior pituitary and in the central nervous system. Somatostatin analogues have antiproliferative effects and are now used in the treatment of several forms of cancer. Somatostatin binds to glycoprotein receptors of the seven transmembrane domain superfamily on target cells.

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SPECIFICATIONS

Catalog Number

DPAB4045

Hosts

Rabbit

Conjugates

Unconj

Target

Somatostatin

Gene Id

6750

Clonality

Polyclonal

Storage Temp

Store the antibody at 4oC for one month or -20oC in undiluted aliquots for one year. Avoid repeated freezing and thawing. Gently spin down material before use; 5-10<br>seconds in a microfuge should be adequate