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Anti-SSTR5 polyclonal antibody

Cat no: CABT-B1627

Anti-SSTR5 polyclonal antibody

Rabbit Anti-Human SSTR5 polyclonal antibody for WB, IHC. Somatostatin receptor type 5 (UniProt P35346; also known as SS-5-R, SS5-R, SS5R) is encoded by the SSTR5 gene (Gene ID 6755) in human. Somatostatin receptor type 5 is an inhibitory G-protein coupled receptor (GPCR) which regulates hormone secretion in the pituitary and in pancreatic islets. SSTR5 uses its PDZ ligand motif to interact with PSD-95/discs large/ZO-1 (PDZ) domain proteins, such as the Golgi-associated protein PIST (also termed GOPC, CAL or FIG), endosomal sorting nexin 27 (SNX27), and the scaffold proteins NHERF-1 & NHERF-3 (PDZ-K1). SNX27 is reported to stabilize SSTR5 by preventing its lysosomal degradation, while NHERF-1 & NHERF-3 mediate SSTR5 plasma membrane localizatin and enable its coupling to signaling partners, such as phospholipase C-?3. PIST stabilizes SSTR5 association with the trans-Golgi network (TGN) before it is recruited to the plasma membrane by NHERF proteins.

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SPECIFICATIONS

Catalog Number

CABT-B1627

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Target

SSTR5

Gene Id

6755

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

SUPPLIER INFO

Creative Diagnostics

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