Anti-Syntaxin-11 polyclonal antibody

Rabbit Anti-Human Syntaxin-11 polyclonal antibody for WB, ICC, IF, EM. Syntaxin-11 (UniProt O75558) is encoded by the STX11 (also known as FHL4, HLH4, HPLH4) gene (Gene ID 8676) in human. Syntaxin-11 belongs to the Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE) family of proteins that mediate membrane fusion events. Syntaxin-11 is an atypical syntaxin lacking a transmembrane domain and associates with intermediate compartment (IC) and post-Golgi membranes through a putative palmitoylation domain, as well as through interaction with other proteins via its coiled-coil forming H3 domain. Syntaxin 11 is enriched in immune cells, although lower levels of the protein can also be found in non-immune system tissues. Syntaxin-11 plays a key role in lymphocyte cytotoxicity, cytokine production and secretion. Stx11-knockout natural killer (NK) cells and cytotoxic T-lymphocytes (TLCs) show impaired degranulation, despite a comparable activation, maturation and expression of the complex-forming partners MUNC18-2 and VTI1B. STX11 gene mutations are linked to the rare autosomal recessive disorder familial hemophagocytic lymphohistiocytosis (FHL) characterized by an increased inflammatory response with abnormal secretion of proinflammatory cytokines.

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