Mouse Anti-Human TGFB1 monoclonal antibody for ELISA, FC. TGF-?1 (transforming growth factor ?1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-?. TGF-? is synthesized as a large protein precursor and then secreted as a complex of TGF-? and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-? to prevent its activity. TGF-? requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-? binds to the integrins ?v?1, ?v?6, ?v?8, and ?8?1 through RGD domain. TGF-? plays an important role in controlling proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-? is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A study has shown that LAP is an activated Treg surface marker.
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