Rabbit Anti-Human TNPO3 polyclonal antibody for WB. Transportin 3 (UniProt Q9Y5L0; also known as Imp12, Importin 12, Limb girdle muscular dystrophy 1F, Transportin-SR, TRN-SR, TRN-SR2) is encoded by the TNPO3 gene (also known as IPO12, LGMD1F, MTR10A, TRNSR) (Gene ID 23534) in human. The transport of macromolecules between cytoplasm and nucleus is mediated by importins and exportins and is regulated by the small GTPase Ran. Importins bind their cargo in the cytoplasm, and the competitive binding of RanGTP induces cargoes release in the nucleus. Most nuclear importins and exportins, including transportin-3 (importin-12), belong to the beta-karyopherin family of proteins. Transportin-3 associates with and mediates the nuclear import of a wide range of serine/arginine-rich/RS domain-containing proteins, the majority of which are involved in mRNA processing, including the cleavage and polyadenylation specificity factor 6 (CPSF6, CF-Im-68) and the splicing factors alternative splicing factor/splicing factor 2 (ASF/SF2) & SC35. In addition, Transportin-3 also plays a cofactor role in facilitating HIV-1 replication. Phosphorylation of the ASF/SF2 RS domain is required for its interaction with Transprotin-3 HEAT repeat 15. Mutations in the HEAT repeat 15 region of Transprotin-3 likewise are reported to impair its interaction with CPSF6 and its ability to support HIV-1 replication.
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