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Anti-umuD polyclonal antibody

Cat no: CABT-BL3735

Anti-umuD polyclonal antibody

Rabbit Anti-Escherichia coli umuD polyclonal antibody for WB. The products of umuD, umuC, and recA genes (SOS genes) are required for mutagenesis induced by radiation or chemical agents. Transcription of these SOS genes is repressed by a repressor, LexA protein in uninduced cells. Exposure of cells to DNA-damaging agents activates RecA protein to promote proteolytic cleavage of LexA protein. Inactivation of LexA protein by the cleavage consequently derepresses the SOS genes, umuD, C and recA. UmuD protein is then auto-cleaved, which is promoted by RecA protein ssDNA in a ATP-dependent manner. The processed UmuD protein is the active form for mutagenesis and the UmuD-UmuC complex functions as an error-prone translesion DNA polymerase.

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SPECIFICATIONS

Catalog Number

CABT-BL3735

Hosts

Rabbit

Conjugates

Unconj

Target

umuD

Gene Id

945746

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Aliquot and store at -80В°C. Avoid repeated freeze / thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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