Anti-uPAR polyclonal antibody

Goat Anti-Mouse uPAR polyclonal antibody for WB, FC, IHC, Block, CyTOF-ready. The urokinase-type plasminogen activator (uPA) is one of two activators that converts the extracellular zymogen plasminogen to plasmin, a serine protease that is involved in a variety of normal and pathological processes that require cell migration and/or tissue destruction. uPA is synthesized and released from cells as a single?chain (sc) pro-enzyme with limited enzymatic activity and is converted to an active two-chain (tc) disulfide-linked active enzyme by plasmin and other specific proteinases. Both the scuPA and tcuPA bind with high-affinity to the cell surface via the glycosyl phosphatidylinositol-linked receptor uPAR which serves to localize the uPA proteolytic activity. The enzymatic activity of scuPA has also been shown to be enhanced by binding to uPAR. Independent of their proteolytic activity, the uPA/uPAR interaction also initiates signal transduction responses resulting in activation of protein tyrosine kinases, gene expression, cell adhesion, and chemotaxis. uPAR can interact with integrins to suppress normal integrin adhesive function and promote adhesion to vitronectin through a high affinity vitronectin binding site on uPAR. Mouse uPAR-1/Fc cDNA encodes a 327 amino acid (aa) residue precursor protein with a 23 aa residue signal peptide, seven potential N-linked glycosylation sites and a C-terminal GPI-anchor site. An alternate spliced variant of uPAR encoding a secreted soluble form of uPAR also exists. Human and mouse uPAR share approximately 60% aa sequence identity and the receptor-ligand interaction is highly species-specific. Human uPA binds rmuPAR at a lower affinity compared to rhuPAR.

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SPECIFICATIONS

Catalog Number

CABT-B9005

Hosts

Goat

Reactivities

Mouse

Target

PLAUR

Gene Id

18793

Isotype

IgG

Clonality

polyclonal

Storage Temp

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.<br/>12 months from date of receipt, -20 to -70В°C as supplied.<br/>1 month, 2 to 8В°C under sterile conditions after reconstitution.<br/>6 months, -20 to -70В°C under sterile conditions after reconstitution.