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Anti-VEGF polyclonal antibody [Alexa Fluor® 488]

Cat no: CABT-B1718

Anti-VEGF polyclonal antibody [Alexa Fluor® 488]

Rabbit Anti-Human VEGF polyclonal antibody for ICC. VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic factor. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties, such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated in response to hypoxia, by activated oncogenes, and by a variety of cytokines. VEGF also enhances permeabilization of blood vessels and plays a central role in the regulation of vasculogenesis. VEGF expression has been linked to the degree of tumor vascularization and with increased metastatic risk. Additionally, VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis. Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors.

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SPECIFICATIONS

Catalog Number

CABT-B1718

Hosts

Rabbit

Reactivities

Hum, Rat

Target

VEGFA

Gene Id

7422

Isotype

IgG

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

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