Anti-Verotoxin II B subunit monoclonal antibody, clone A258

Mouse anti-Verotoxin II B subunit monoclonal antibody for ELISA, Neut. Suitable for use in ELISA and Neutralization. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excludedShiga-like toxin, alsoknown as verotoxin, is a toxin generated by some strains of Escherichia coli(but see below). It is named for its similarity to the AB5-type Shiga toxinproduced by the bacteria Shigella dysenteriae.There are two types, known asSLT1 and SLT2. Verotoxins are produced by certainenterohaemorrhagic strains of Escherichia coli. Serotype O157:H7 has been thestrain most commonly associated with large food bourne outbreaks and has beenimplicated in a wide spectrum of diseases including blood diarrhoea,haemorrhagic colitis and haemolytic uraemic syndrome. The main sources ofinfection are contaminated foods of animal origin such as meat and dairyproducts. Verotoxins, also called Shiga like toxins( SLT) because of theirsimilarity to toxins produced by Shigella dysenteriae, are classified intotwo main categories: verotoxin 1 (VT1, SLT1, Stx1) and 2 (VT2, SLT2, Stx2).Verotoxin production is the most common criteria for the detection of thisgroup of bacteria rather than tests for the cytopathic effect on Vero cellsthat gave the toxins their name. Verotoxins contain a single A subunit andmultiple copies of a B subunit.The A subunit is responsible for inhibiting protein synthesis through thecatalytic inactivation of 60S ribosomal subunits.

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