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Anti-VPA monoclonal antibody, clone A805

Cat no: DMAB4496

Anti-VPA monoclonal antibody, clone A805

Mouse anti-VPA monoclonal antibody for IA. Valproic acid, valproatesodium and divalproex belong to the group of medicines calledanticonvulsants, used to control certain types of seizures in the treatmentof epilepsy. Also, valproic acid relieves histone deacetylases (HDACs)dependent transcriptional repression and causes hyperacetylation of histonesin cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro,most probably by binding to the catalytic centre of HDACs. Most importantly,valproic acid induces differentiation of carcinoma cells, transformedhaematopoietic progenitor cells and leukaemic blasts from acute myeloidleukaemia patients. Moreover, tumour growth and metastasis formation aresignificantly reduced in animal experiments. Therefore, valproic acid mightserve as an effective drug for cancer therapy

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SPECIFICATIONS

Catalog Number

DMAB4496

Hosts

Mouse

Conjugates

Unconj

Clone

A805

Target

Valproic Acid

Isotype

IgG1

Clonality

Monoclonal

Storage Temp

Store (up to one year) at -20°C to –70°C. Avoid multiple freeze/thaw cycles.

SUPPLIER INFO

Creative Diagnostics

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