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Anti-VPA monoclonal antibody, clone A805

Cat no: DMAB4496


Supplier: Creative Diagnostics
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Mouse anti-VPA monoclonal antibody for IA. Valproic acid, valproatesodium and divalproex belong to the group of medicines calledanticonvulsants, used to control certain types of seizures in the treatmentof epilepsy. Also, valproic acid relieves histone deacetylases (HDACs)dependent transcriptional repression and causes hyperacetylation of histonesin cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro,most probably by binding to the catalytic centre of HDACs. Most importantly,valproic acid induces differentiation of carcinoma cells, transformedhaematopoietic progenitor cells and leukaemic blasts from acute myeloidleukaemia patients. Moreover, tumour growth and metastasis formation aresignificantly reduced in animal experiments. Therefore, valproic acid mightserve as an effective drug for cancer therapy
Catalogue number: DMAB4496
Hosts: Mouse
Conjugates: Unconjugated
Clone: A805
Target: Valproic Acid
Isotype: IgG1
Clonality: Monoclonal
Storage temp: Store (up to one year) at -20°C to –70°C. Avoid multiple freeze/thaw cycles.

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