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Anti-VPS41 (C-terminal half) polyclonal antibody

Cat no: CABT-B1565

Anti-VPS41 (C-terminal half) polyclonal antibody

Rabbit Anti-Human VPS41 polyclonal antibody for WB, ICC. Vacuolar protein sorting-associated protein 41 homolog (UniProt P49754; also known as hVps41p, S53, Vacuolar assembly protein 41) is encoded by the VPS41 (also known as HVPS41, HVSP41) gene (Gene ID 27072) in human. Mammalian homolog of yeast VPS41 is a component of the homotypic fusion and vacuole protein sorting (HOPS) complex involved in both endocytic and exocytic membrane vesicle trafficking. The N-terminal region of Rab interacting lysosomal protein (RILP) is reported to interact with VPS41 C-terminal region. Such interaction is critical for RILP-mediated recruitment of HOPS to the late endosomal compartment and endocytic trafficking. Peptide hormones and many growth factors destined for regulated secretion undergo storage within secretory granules or large dense core vesicles (LDCVs) competent for regulated exocytosis. VPS41 is shown to self-associate via its C-terminal clathrin heavy chain repeat (CHCR) into a coat-like assembly that drives membrane invagination in the process of LDCVs formation.

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SPECIFICATIONS

Catalog Number

CABT-B1565

Hosts

Rabbit

Reactivities

Hum

Target

VPS41

Gene Id

27072

Clonality

Polyclonal

Storage Temp

Stable for 1 year at 2-8В°C from date of receipt.

SUPPLIER INFO

Creative Diagnostics

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