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anti-Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Internal Region) antibody

Cat no: ABIN964686

anti-Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Internal Region) antibody

anti-Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Internal Region) antibody: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt1 (Wingless-type MMTV integration site family member 1) is a member of the WNT gene family. It is highly conserved in evolution and the protein encoded by this gene is known to be 98% identical to mouse Wnt1 protein at the amino acid level. Studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. Wnt1 is secreted as an extracellular matrix protein.

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SPECIFICATIONS

Catalog Number

ABIN964686

Size

25 micro L

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

13F9

Antigen

Wnt1

Gene Id

7471

Isotype

IgG1 kappa

Accession

P04628

Clonality

Monoclonal

Concentration

1.0 mg/mL

Entrez Gene Id

7471

SUPPLIER INFO

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