Anti-XPC polyclonal antibody

Rabbit Anti-Human XPC polyclonal antibody for WB. DNA repair protein complementing XP-C cells (UniProt Q01831; also known as xeroderma pigmentosum group C-complementing protein, p125) is encoded by the XPC (also known as RAD4, XP3, XPCC) gene (Gene ID 7508) in human. Nucleotide excision repair (NER) removes damage to DNA caused by UV and mutagens. The NER process involves damage recognition and formation of an open DNA structure around the lesion, followed by dual incision, excision of an oligonucleotide of 24 to 32 residues, and gap-filling DNA synthesis to restore the DNA molecule. In human, the minimal set of components involved in NER includes replication protein A (RPA), XPA, XPC-RAD23B, XPG, ERCC1-XPF, TFIIH, replication factor C (RFC), PCNA, DNA polymerase ? or ??, and DNA ligase I. These factors can be divided into two groups, the six core factors necessary for damage recognition and dual incision (RPA, XPA, XPC-RAD23B complex, XPG, ERCC1-XPF, and TFIIH) and those for repair DNA synthesis in the gap-filling step. XPC is specifically involved in global genome NER (GG-NER) and serves as a damage recognition protein in complex with RAD23B. XPC is the rate-limiting factor in the GG-NER process, and XPC-dependent distortion recognition plays an essential role in initiating the recruitment of core NER proteins to the lesion.

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SPECIFICATIONS

Catalog Number

CABT-B1583

Hosts

Rabbit

Reactivities

Hum, Mouse

Target

rad4

Gene Id

7508

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.