Anti-ZMYND11 (C-terminal) polyclonal antibody

Rabbit Anti-Mouse ZMYND11 polyclonal antibody for WB, ChIPseq, ChIP. Zinc finger MYND domain-containing protein 11 (UniProt Q8R5C8) is encoded by the Zmynd11 gene (Gene ID 66505) in murine species. ZMYND11/BS69 functions as a co-repressor of adenovirus E1A and cellular transcription factors including the c-Myb and ETS-2 oncoproteins. ZMYND11 contains several histone reader motifs, including a plant homeodomain (PHD), a bromodomain, and a PWWP domain. Lys36-trimethylated histone H3 (H3K36me3) is deposited onto the nucleosomes in the transcribed regions after RNA polymerase II elongation, and ZMYND11 is found to specifically recognize H3K36me3 and regulate RNA polymerase II elongation. Binding study showed that the combined PHD-bromo-PWWP (PBP) module mediates ZMYND11 recognition of H3K36me3 and PWWP domain alone displays little to no affinity toward H3K36me, H3K36me2, or unmethylated H3K36. ZMYND11 is a tumor suppressor that functions as an unconventional transcription co-repressor by modulating RNA polymerase II at the elongation stage. Low expression levels of ZMYND11 in breast cancer patients correlate with poor prognosis. Consistently, ZMYND11 overexpression suppresses cancer cell growth in vitro and tumor formation in mice in vivo.

Prices direct from Creative Diagnostics

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

CABT-B1690

Applications

ChIP

Hosts

Rabbit

Reactivities

Hum

Target

ZMYND11

Clonality

Polyclonal

Storage Temp

Stable for 1 year at -20В°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20В°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.