Antibiotic RK-682 (Antibiotic TAN 1364B, Antibiotic CI 010)

Antibiotic RK-682 is the calcium salt of one of a complex family of tetronic acids isolated from Streptomyces species. The formation of the salt is almost certainly an artefact of silica chromatography. RK-682 is the most extensively studied of the analogues, having been shown to inhibit protein tyrosine phosphatases and heparanase. Pharmacological studies with RK-682 demonstrated enhanced ATP-induced long-term potentiation using guinea-pig hippocampal slices. Investigation of the complex has also shown potent activity against HIV-1 protease.\n\nPurity: >95% by HPLC\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO.

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SPECIFICATIONS

Catalog Number

A2297-30

Size

500ug

Purity

>95% by HPLC

References

1. RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at \nG1phase. Hamaguchi T. et al. FEBS Lett. 1995, 372, 54. 2. Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. Ishida K. et al. Mol. Cancer. Ther. 2004, 3, 1069. 3. The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons. Fujii S. et al. Neurosci. Lett. 1995, 187, 130. 4. 3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. Roggo B.E. J. Antibiot. 1994, 47, 136.

Alternative Names

Antibiotic TAN 1364B, Antibiotic CI 010