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Antibiotic UCN-02 (UCN 02)

Cat no: A2297-39A

Antibiotic UCN-02 (UCN 02)

UCN-02 is isolated as a minor co-metabolite of high producing staurosporine strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. \n\nPurity: >95% by HPLC\n\nSolubility: Soluble in ethyl acetate, ethanol, DMF or DMSO.\n\nRelated to: Staurosporine, Antibiotic UCN-01

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SPECIFICATIONS

Catalog Number

A2297-39A

Size

1mg

Purity

>95% by HPLC

References

1. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of \nmitogen-activated protein/extracellular signal-regulated kinase/extracellular signal-regulated kinase \npathway. Facchinetti M.M. et al. Cancer Res. 2004, 64, 3629. 2. UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti- cancer agents for the new century? Akinaga S. et al. Anticancer Drug Des. 2000, 15, 43. 3. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. Takahashi I. et al. J. Antibiot. 1989, 42, 571.

Alternative Names

UCN 02

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Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info
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