Antiplasmin, alpha2 (Alpha-2-antiplasmin, Alpha-2-AP, AAP, A2AP, Alpha-2-plasmin Inhibitor, Alpha-2-PI, API, PLI, Serpin F2, SERPINF2)

Alpha-2 antiplasmin is a single-chain glycoprotein with a molecular weight of about 65000. The normal concentration in human plasma is 60ug/ml. Platelets contain significant amounts of the protein, which is released along with platelet factor 4, following thrombin stimulation. It can form 1:1 complexes with circulating plasmin. Alpha-2 antiplasmin is the most important inhibitor of plasmin-mediated fibrinolysis, but also capable of inactivating factor XIIa, kallikrein, factor XIa, thrombin and factor Xa. The importance of the alpha-2 antiplasmin as a regulator of the fibrinolytic system was detected by the discovery of a congenital deficiency. \n\nApplications: \nSuitable for use in ELISA, Immunoprecipitation, Immunoelectrophoresis and Double Radial Immunodiffusion. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A2298-13S

Size

1ml

Applications

ELISA, IP

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a lyophilized powder. Reconstitute in 1ml sterile ddH2O. Dilute further in PBS, pH 7.2.

P Type

Pab

Purity

Serum

Isotype

IgG

Additional Info

Recognizes human alpha-2 antiplasmin. A single precipitin line is obtained in bidimensional electrophoresis, immunoelectrophoresis and double radial immunodiffusion (Ouchterlony) which shows a reaction of full identity with the purified immunogen. Does not crossreact with any other human plasma proteins.

Alternative Names

Serpin Peptidase Inhibitor, Clade F (alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 2