APC (Adenomatous Polyposis Coli, APC, DP2, DP2.5, DP3, FAP, FPC, GS)

APC is well suited for immunohistochemical and immunofluorescence studies of oligodendrocytes and optic nerves due to the antibodys staining of the cell body as opposed to the myelinated processes.\n\nCellular Localization: Secreted\n\nApplications: \nSuitable for use in Immunofluorescence and Immunohistochemistry (paraffin-embedded sections). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A2298-69F

Size

50ug

Applications

IF, IHC

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Form

0.1% Sodium Azide; 0.2% Gelatin, 0.05M Sodium phosphate

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2b

References

Bhat RV et al. Expression of the APC tumor suppressor protein in oligodendroglia. Glia 17:169-74 (1996). Bhat RV et al. High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system. J Neurosci 14:3059-71 (1994). Smith KJ et al. Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res 54:3672-5 (1994). Smith KJ et al. The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A 90:2846-50 (1993). Su LK et al. Association between wild type and mutant APC gene products. Cancer Res 53:2728-31 (1993). Su LK et al. Association of the APC tumor suppressor protein with catenins. Science 262:1734-7 (1993). Groden J et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589-600 (1991). Kinzler KW et al. Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251:1366-70 (1991).

Additional Info

This antibody has been shown to detect oligodendrocytes and astrocytes. Species Crossreactivity: Crossreacts with Human, Mouse and Rat.

Alternative Names

Adenomatous Polyposis Coli, APC, DP2, DP2.5, DP3, FAP, FPC, GS