APC anti-human CD215 (IL-15Ralpha)

IL-15 receptor alpha (IL-15Ralpha) is a cytokine receptor with the structural homology to IL-2Ralpha (CD25). Both alpha receptors contain a group of beta sandwich protein called sushi domains. Similar to IL-2Ralpha, IL-15Ralpha is able to form a heterotrimer with their beta chain (CD122) and common gamma chain (gammac, CD132). But unlike IL-2Ralpha subunit, IL-15Ralpha itself binds to IL-15 with equivalent high affinity compared with the heterotrimeric complex. IL-15Ralpha is expressed as soluble or transmembrane forms by variety cells, such as activated monocytes, dendritic cells, CD8+ memory T cells, NK or NKT cells. IL-15Ralpha by itself forms stable complexes with IL-15 on cell surface and presents IL-15 in trans to neighboring cells. IL-15, like IL-2, is a pleiotropic four-helix bundle cytokine and plays a key role in promoting T and B cell survival and proliferation, preferentially in memory CD8+ T cell proliferation, and NK/NKT cell development.

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SPECIFICATIONS

Catalog Number

330209

Size

25 tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

JM7A4

Gene Id

3601

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

IL-15R a chain

Regulatory Status

RUO