APC anti-mouse CD88 (C5aR)

Cat no: 135808

Supplier: BioLegend

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Description
Additional Information

CD88 is a single chain protein with seven membrane-spanning regions and a molecular weight of 43 kD. CD88 is expressed by neutrophils, eosinophils, and monocytes. There have been reports of CD88 expression in non-immune cells such as glial cells, cerebellar granule cells, cardiomyocytes, and vascular endothelial cells. CD88 is coupled to heterotrimeric G proteins such as Gi, and after C5a binding, the signal transduced by CD88 results in the activation of PLCbeta, PI-3 kinase, and PLA2, among other molecules, resulting in chemotaxis, granule enzyme release, and superoxide anion production.

Catalogue number:	135808
Reactivities:	Mouse
Hosts:	Rat
Applications:	Flow Cytometry
Size:	100 microg
Clone:	20/70
Gene:	12273
Dilutions:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer:	The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration:	0.2 mg/ml
Antigen:	mC5aR transfected cells
Isotype:	Rat IgG2b, kappa
Clonality:	Monoclonal
Regulatory status:	RUO
Shipping temp:	Ambient RT
Storage temp:	4 C
Alternative names:	C5a ligand, C5a anaphylatoxin receptor, C5AR, C5R1, C5AR1