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APC10 (Anaphase Promoting Complex 10, ANAPC10, DKFZP564L0562, DOC1)

APC10 (Anaphase Promoting Complex 10, ANAPC10, DKFZP564L0562, DOC1)

Cat no: A2298-72N

Supplier: United States Biological
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APC is a ubiquitin ligase which specifically targets mitotic regulatory factors such as Pds 1/Cut 2 and cyclin B. It was found that APC 10/Doc 1 is localized in centrosomes and mitotic spindles throughout mitosis, while it is also localized in kinetochores from prophase to anaphase and in mid body in telophase and cytokinesis. These results strongly support the notion that human APC 10/Doc 1 may be one of the APC core subunits rather than the transiently associated regulatory factor. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2298-72N
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: 0.01% Sodium Azide; 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Anaphase Promoting Complex Subunit 10
References: Jentsch S, Pyrowolakis G. (2000) Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 10(8):335-42. Tang,Z., Li,B., Bharadwaj,R., Zhu,H., Ozkan,E., Hakala,K., Deisenhofer,J. and Yu,H. (2001) APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol. Biol. Cell 12 (12), 3839-3851.
Additional info: This antibody detects a band at about 26kD that corresponds to Apc10. Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (100% identity with immunogen) due to sequence homology.

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