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APETx2

Cat no: RTA-100

APETx2

APETx2. A Blocker of ASIC3 Channel
Natural APETx2 is a 42-amino-acid peptidyl toxin, originally isolated from the sea anemone Anthopleura elegantissima. APETx2 was shown to be a selective, potent and reversible blocker of the homodimer proton gated channel ASIC3. ASIC3 has been implicated in pain transduction associated with acidosis in inflamed or ischemic tissues. APETx2 directly inhibits the ASIC3 channel by acting at its external side of the channel in a pH dependent manner.
APETx2 also inhibits the hetromer ASIC2b-ASIC3 channel but does not inhibit the activity of ASIC1 isoform.
Structurally APETx2 is related to APETx1 a toxin that targets HERG K+ channel.

Alomone Labs is pleased to offer APETx2, a recombinant protein expressed and purified from E. coli.
Ion Channel Modulators; ASIC Channel Blockers.

Prices direct from Alomone Labs Ltd.

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SPECIFICATIONS

Catalog Number

RTA-100

Size

5 x 5 micro g

Purity

>98%

Concentration

10 nM - 3 micro M.

Shipping Temp

Room Temperature

Molecular Weight

4561 da

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