Home  >  Products  >  APEX1 (DNA-(apurinic or apyrimidinic site) lyase, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APEX nuclease, APEN, Protein REF-1, APEX1, APE, APEX, APX, HAP1, REF1)
APEX1 (DNA-(apurinic or apyrimidinic site) lyase, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APEX nuclease, APEN, Protein REF-1, APEX1, APE, APEX, APX, HAP1, REF1)

APEX1 (DNA-(apurinic or apyrimidinic site) lyase, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APEX nuclease, APEN, Protein REF-1, APEX1, APE, APEX, APX, HAP1, REF1)

Cat no: A2298-74C7

Supplier: United States Biological
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Human A (MW: 38kD) endonuclease-1 (HAP-1), also known as APE, APEX or Ref-1, is a nuclear enzyme that repairs apurinic/apyramidinic sites in cellular DNA. Human AP endonucleases-1 cleaves the phosphodiesterase followed by filling-in of the nucleotide gap by DNApolymerase. HAP-1 has been detected in a wide range of human tissues including bladder, breast, small and large intestine, lung, ovary, pancreas, skin, spleen, testis, thymus and thyroid. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2.5-5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HepG2 cells. Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A2298-74C7
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human APE-1.

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