Aphidicolin is a tetracyclic diterpene antibiotic isolated from species in several genera of fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties blocking the cell cycle at early S-phase. This property has been used to synchronize cell division and has found use as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibition of selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
Nomenclature: 3-a,4-a,5-a,17-a-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Melting Point:
225-233 degrees C
Appearance:
Supplied as a white to off-white crystalline powder.
Solubility:
Soluble in DMSO (50mg/ml). Also soluble in Ethanol and Methanol.
Handling:
Warning! Toxic. Aphidicolin may be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure.
Storage and Stability:
Lyophilized powder may be stored at 4 degrees C. Lyophilized powder is stable for 12 months as supplied. Reconstitute to nominal volume by adding DMSO, ethanol or methanol. Aliquot and store at -20 degrees C. Reconstituted product is stable for 1-2 months at -20 degrees C. Further dilutions can be made in assay buffer.
Note: Aphidicolin extremely hygroscopic. Protect from moisture. Store in tightly sealed vial under inert gas. Warm to RT before opening container.
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