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Apicidin

Cat no: A2298-79


Supplier: United States Biological
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Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50
Catalogue number: A2298-79
Size: 2mg
Form: Supplied as an off-white lyophilized powder.
Purity: (same/more than) 95% by HPLC
Alternative names: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl); Apicidin Ia; OSI 2040
References: 1. Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Kim S.H. et al. Biochem. Biophys. Res. Commun. 2004, 315, 964. 2. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Han J.W. et al. Cancer Res. 2000, 60, 6068.

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