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APOBEC2 (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-like 2, ARCD1, ARP1, OTTHUMP00000039773, Catalytic Polypeptide 2)

APOBEC2 (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-like 2, ARCD1, ARP1, OTTHUMP00000039773, Catalytic Polypeptide 2)

Cat no: A2298-88L

Supplier: United States Biological
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This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128000. Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2298-88L
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Prochnow C, Bransteitter R, Klein MG, Goodman MF, Chen XS. The APOBEC-2 crystal structure and functional implications for the deaminase AID. Nature. 2007 Jan 25;445(7126):447-51. Epub 2006 Dec 24.
Additional info: Recognizes APOBEC2 at ~26kD in Human Muscle lysates (calculated MW of 25.7kD according to NP_006780.1). Species Crossreactivity: Canine, mouse and rat.

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