Apolipoprotein E (Apolipoprotein-E, Apo E, ApoE, Apo-E, Alzheimer Disease 2, AD2, Apolipoprotein E3, APOE3, Apoprotein, LDLCQ5, LPG, MGC1571)

Lipoproteins are responsible for carrying cholesterol and other fats through the bloodstream as little packages and are essential for the normal breakdown of these molecules. In particular, apolipoprotein E is a major component of specific lipoproteins called very low-density lipoproteins (VLDL). A major function of VLDLs is to remove excess cholesterol from the blood and carry it to the liver for processing. Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular diseases, including heart attacks and strokes. Apolipoprotein E is a type of lipoprotein. Apolipoprotein E is associated with several cardiovascular disorders. There are three isoforms (slightly different forms) of the ApoE lipoprotein. These three isoforms are known as ApoE2, E3 and E4. ApoE2 seems to be one of several genetic factors that plays a part in increased risk of heart attacks and strokes and ApoE4 is a risk factor for coronary artery disease. As well, ApoE4 has been been suggested to play a role in type 2 Alzheimer

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

A2299-74C

Size

1ml

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder. Reconstitute with 1ml sterile ddH2O.

P Type

Mab

Purity

Purified by ammonium sulfate precipitation and DEAE chromatography.

Isotype

IgG1

References

1. Dergunov, A.D., et al., Biol. Chem. 373: 323-331 (1992). 2. Babaev, V.R., et al., Artherosclerosis 85: 239-247 (1990).

Additional Info

Recognizes human Apo-E. Recognizes all alleles of Apo-E. Reacts with very low density lipoproteins (VLDL) of human plasma. Reacts as well with LDL as with VLDL. No crossreactions with other human plasma proteins are observed.