Home  >  Products  >  Apoptosis Antagonizing Transcription Factor (AATF, CHE1, CHE-1, DED, HSPC277, Protein AATF, Rb-binding Protein Che-1)
Apoptosis Antagonizing Transcription Factor (AATF, CHE1, CHE-1, DED, HSPC277, Protein AATF, Rb-binding Protein Che-1)

Apoptosis Antagonizing Transcription Factor (AATF, CHE1, CHE-1, DED, HSPC277, Protein AATF, Rb-binding Protein Che-1)

Cat no: A2299-90R

Supplier: United States Biological
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AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid -peptide and to inhibit aberrant production of the -peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer
Catalogue number: A2299-90R
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Apoptosis-antagonizing Transcription Factor
Additional info: Recognizes human AATF. Species Crossreactivity: rat.

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