APP Antibody

Cat no: 250545

Supplier: ABBIOTEC

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Description
Additional Information

The Amyloid Protein Precursor (APP) is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase comple, Xenopus/Amphibian, APBB1/TIP60 to promote transcriptional activation, whereas others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). In addition, APP is associated with neurological disorders related to type II diabetes and Down's syndrome.

Catalogue number:	250545
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P05067
Antigen:	KLH-conjugated synthetic peptide encompassing the human APP695 sequence.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Mouse Polyclonal Antibody
Isotype:	Mouse Ig
Additional info:	Amyloid beta A4 protein; Alzheimer disease amyloid protein; ABPP; APPI; APP PreA4; Cerebral vascular amyloid peptide; CVAP; Protease ne, Xenopus/Amphibian,in-II; PN-II; A4; APP; AD1