AR-alpha2A (R361) Peptide

Cat no: BS2254P

Supplier: Bioworld Technology, Inc.

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This study investigates the involvement of alpha2-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha2A-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal alpha2A-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, alpha1D-AR, were not changed by the treatment. Moreover, alphao-subunits of GTP-binding proteins (Galphao), one of the downstream molecules of alpha2A-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of alpha2A-AR in the mouse hippocampus.

Catalogue number:	BS2254P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P08913
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide AR-alpha2A (R361). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR; ADRA2A; ADRA2R; ADRAR; alpha-2A adrenoceptor; alpha-2AAR; ARalpha-2A; AR alpha2A; ARalpha2A; ARalpha 2A;
Additional info:	This peptide can be used with studies using BS2254 AR-alpha2A (R361) pAb.

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AR-alpha2A (R361) Peptide

Cat no: BS2254P

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