ARA9 (XAP2, Ah Receptor Associated Protein, ARA9, AIP)

Ah receptor-associated protein (ARA9) is also known as AIP and XAP2. This protein displays structural similarity to the glucocorticoid receptor-associated immunophilin FKBP52. Although they share significant homology, they have distinct cellular roles and biochemical properties. ARA9 is known to affect the potency and efficacy of AHR agonists in the yeast Saccharomyces cerevisiae as well as having functional consequence on AHR signal transduction.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000. Band is seen at 37kD, representing ARA9\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

A3290

Size

100ul

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid.

P Type

Mab

Purity

Ascities

Isotype

IgG1

References

1. Carver, Lucy A., et al. Characterization of the Ah Receptor-associated Protein, ARA9. The Journal of Biological Chemistry. 273(50): 33580-33587, 1998.\n2. Carver, Lucy A., and Bradfield, Christopher A. Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo. The Journal of Biological Chemistry. 272(17): 11452-11456, 1997.\nGeneral References:\n1. Petrulis, John R., et al. Subcellular Localization of the Aryl Hydrocarbon Receptor is Modulated by the Immunophilin Homolog Hepatitis B Virus X-associated Protein 2*. The Journal of Biological Chemistry. 275(48):37448-37453, 2000.

Additional Info

Specific for ARA9 FKBP domain. \nSpecies Crossreactivity: Human and mouse.