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Aranorosin

Cat no: 044569


Supplier: United States Biological
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Antibiotic. Antibacterial. Antifungal. Anticancer compound. Inhibits anti-apoptotic functions regulated by Bcl-2. Circumvents arbekacin (ABK)-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2''). Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 3 years after receipt when stored at -20 degrees C.
Catalogue number: 044569
Size: 250ug
Purity: >95% (HPLC)
References: Product Reference: ?Aranorosin, a novel antibiotic from Pseudoarachniotus roseus. I. Taxonomy, fermentation, isolation, chemical and biological properties: K. Roy, et al.; J. Antibiot. (Tokyo) 41, 1780 (1988) ?Aranorosin, a novel antibiotic from Pseudoarachniotus roseus. II. Structure elucidation: H.W. Fehlhaber, et al.; J. Antibiot. (Tokyo) 41, 1785 (1988) ?Structure of aranorosin, a new antibiotic of a novel skeletal type: H.W. Fehlhaber, et al.; JACS 110, 8242 (1988) ?Stereoselective synthesis of the functionalized spirocyclic core of aranorosin: P. Wipf & Y. Kim; J. Org. Chem. 58, 1649 (1993) ?Structure of a model for the aranorosin nucleus: R. C. Haltiwanger, et al.; Acta Cryst. C 50, 274 (1994) ?Structure-activity relationships of new aranorosin analogs to antifungal activity: E.K. Vijayakumar, et al.; J. Antibiot. (Tokyo) 51, 522 (1998) ?Aranorosin and a novel derivative inhibit the anti-apoptotic functions regulated by Bcl-2: T. Nakashima, et al.; BBRC 377, 1085 (2008) ?Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC(6')/APH(2''): T. Suga, et al.; J. Antibiot. (Tokyo) (Epub ahead of print) (2012) ?

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