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Arc, p16, NT (Actin Related Protein 2/3 Complex, Subunit 5, 16kD, ARPC5, dJ127C7.3)

Arc, p16, NT (Actin Related Protein 2/3 Complex, Subunit 5, 16kD, ARPC5, dJ127C7.3)

Cat no: A0760-88A

Supplier: United States Biological
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The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc (p complex) (1). These proteins localize in the cytoplasm of fibroblasts that lack lamellipodia, but are enriched in lamellipodia on stimulation with serum or platelet-derived growth factor. A dynamic role for this complex in the organization of the actin cytoskeleton has been suggested (2). p16-Arc has been found to be a globular alpha-helical subunit (3). Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:20 Western Blot: 1:1000-1:10,000 Immunoprecipitation: 1:70 Immunohistochemistry: 1:50-1:100 Immunocytochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: A0760-88A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Welch, M.D., et al., J. Cell Biol. 138(2): 375-384 (1997). 2. Machesky, L.M., et al., Biochem. J. 328(1): 105-112 (1997). 3. Robinson, R.C., et al., Science 294(5547): 1679-1684 (2001).
Additional info: Recognizes human p16-Arc at 16kD. Species Crossreactivity: mouse, rat

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