Home  >  Products  >  ARMER, CT (ADP-ribosylation Factor-like Protein 6-interacting Protein 1, ARL-6-interacting Protein 1, AIP1, Aip-1, ARL6IP1, ARL6IP, KIAA0069)
ARMER, CT (ADP-ribosylation Factor-like Protein 6-interacting Protein 1, ARL-6-interacting Protein 1, AIP1, Aip-1, ARL6IP1, ARL6IP, KIAA0069)

ARMER, CT (ADP-ribosylation Factor-like Protein 6-interacting Protein 1, ARL-6-interacting Protein 1, AIP1, Aip-1, ARL6IP1, ARL6IP, KIAA0069)

Cat no: A3571-05D

Supplier: United States Biological
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Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases andultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human bladder cell lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A3571-05D
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
Alternative names: ADP-ribosylation Factor-like 6 Interacting Protein 1
References: 1. Stellar H. Mechanisms and genes of cellular suicide. Science 1995; 267:1445-9. 2. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98-103. 3. Lui HM, Chen J, Wang L, et al. ARMER, Apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. Mol. Cancer Res. 2003; 1:508-18.
Additional info: Recognizes human ARMER. Species Crossreactivity: mouse.

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