Home  >  Products  >  ARP1 homolog A (ACTR1A, Actin-Related Protein 1 Homolog A, Centractin alpha (yeast), Actin-RPV, Alpha-Centractin, ARP1, Centractin, Centrosome-associated Actin Homolog, CTRN1)
ARP1 homolog A (ACTR1A, Actin-Related Protein 1 Homolog A, Centractin alpha (yeast), Actin-RPV, Alpha-Centractin, ARP1, Centractin, Centrosome-associated Actin Homolog, CTRN1)

ARP1 homolog A (ACTR1A, Actin-Related Protein 1 Homolog A, Centractin alpha (yeast), Actin-RPV, Alpha-Centractin, ARP1, Centractin, Centrosome-associated Actin Homolog, CTRN1)

Cat no: A0857-40C

Supplier: United States Biological
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his gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A0857-40C
Reactivities: Human, Mouse, Rat
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Lees-Miller JP, Helfman DM, Schroer TA. A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. Nature. 1992 Sep 17;359(6392):244-6.
Additional info: Recognizes ARP1 at ~45kD in human brain lysates (predicted MW of 43kD according to NP_005727). This epitope was selected to minimise the chance of cross-reactivity with ACTR1B (YEEDGSRAIHRKT). Species Crossreactivity: Mouse and rat.

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