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Arrestin 1, beta (ARRB1, ARB1, ARR1)

Arrestin 1, beta (ARRB1, ARB1, ARR1)

Cat no: A3576-98D

Supplier: United States Biological
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The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001). Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:500 Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A3576-98D
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% sodium azide.
P type: Mab
Isotype: IgM,k
Purity: Purified by ammonium sulfate precipitation.
References: 1. Miller, W.E., and R.J. Lefkowitz. (2001). Curr. Opin. Cell Biol. 13: 139-145. 2. Lefkowitz, R.J. (1998). J. Biol. Chem. 273: 18677-80. 3. Lin, F.T., et al. (1998). J Biol Chem. 273: 31640-3.
Additional info: Recognizes human beta arrestin 1.

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