Arrestin 2, beta (ARRB2, ARB2, ARR2, DKFZp686L0365, HGNC:712)

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin

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SPECIFICATIONS

Catalog Number

A3577-02A

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Rat

Form

Supplied as a liquid in PBS, 1 mg/ml BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Mundell SJ et al. Characterization of arrestin expression and function. Methods Enzymol 343:600-11 (2002). 2. McDonald PH & Lefkowitz RJ Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cell Signal 13:683-9 (2001). 3. Penn RB et al. Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J Biol Chem 276:32648-56 (2001).

Additional Info

Detects recombinant rat beta-arrestin and beta-arrestin 2. Does not detect visual or cone arrestin.