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Arrestin 2, beta (ARRB2, ARB2, ARR2, DKFZp686L0365, HGNC:712)

Arrestin 2, beta (ARRB2, ARB2, ARR2, DKFZp686L0365, HGNC:712)

Cat no: A3577-02A

Supplier: United States Biological
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Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin
Catalogue number: A3577-02A
Reactivities: Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1 mg/ml BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Mundell SJ et al. Characterization of arrestin expression and function. Methods Enzymol 343:600-11 (2002). 2. McDonald PH & Lefkowitz RJ Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cell Signal 13:683-9 (2001). 3. Penn RB et al. Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J Biol Chem 276:32648-56 (2001).
Additional info: Detects recombinant rat beta-arrestin and beta-arrestin 2. Does not detect visual or cone arrestin.

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