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Arylsulfatase A (ARSA, MLD, cerebroside-sulfatase, cerebroside 3-sulfatase)

Arylsulfatase A (ARSA, MLD, cerebroside-sulfatase, cerebroside 3-sulfatase)

Cat no: A3596-51

Supplier: United States Biological
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ARSA hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this protein lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. Applications: Suitable for use in ELISA, Western Blot. Other applications not tested. Recommended Dilution: Peptide ELISA: 1:32,000. Western Blot: 0.5-1.5ug/ml. A band at ~55kD is observed in Mouse Testis lysates. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Peptide Blocking: Corresponding peptide is available for Peptide Blocking studies. See A3596-51-P. Antibody
Catalogue number: A3596-51
Reactivities: Human, Mouse, Rat
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by affinity chromatography.
Alternative names: ARSA; arylsulfatase A; MLD; cerebroside-sulfatase; cerebroside 3-sulfatase
References: Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy., Sevin C, Benraiss A, Van Dam D, Bonnin D, Nagels G, Verot L, Laurendeau I, Vidaud M, Gieselmann V, Vanier M, De Deyn PP, Aubourg P, Cartier N. , Hum Mol Genet. 2006 Jan 1;15(1):53-64. Epub 2005 Nov 25.
Additional info: Recognizes human Arylsulfatase A. Species Crossreactivity: mouse, rat

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