Ascomycin is a macrocyclic lactone closely related to fujimycin and rapamycin. It is isolated from several species in the genus Streptomyces and was first reported in 1988. Ascomycin exhibits limited potent antifungal activity but has found considerable utility as an immunosuppressant.
Source:
Ascomycin from Stretomyces hygroscopicus.
Molecular Weight:
~792
Solubility:
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.