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AST-1306

AST-1306

Cat no: 002920

Supplier: United States Biological
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AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor.
Catalogue number: 002920
Size: 5mg
Alternative names: N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide; N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6;
References: Xie, H. et al.: PLoS One, 6, e21487 (2011); Bai, F. et al.: Bioorg. Med. Chem. Lett., 22, 1365 (2012);

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