Home  >  Products  >  Atg4B (Cysteine Protease ATG4B, Autophagy-related Protein 4 Homolog B, Autophagin-1, Autophagy-related Cysteine Endopeptidase 1, AUT-like 1 Cysteine Endopeptidase, APG4B, AUTL1, KIAA0943)
Atg4B (Cysteine Protease ATG4B, Autophagy-related Protein 4 Homolog B, Autophagin-1, Autophagy-related Cysteine Endopeptidase 1, AUT-like 1 Cysteine Endopeptidase, APG4B, AUTL1, KIAA0943)

Atg4B (Cysteine Protease ATG4B, Autophagy-related Protein 4 Homolog B, Autophagin-1, Autophagy-related Cysteine Endopeptidase 1, AUT-like 1 Cysteine Endopeptidase, APG4B, AUTL1, KIAA0943)

Cat no: A2298-74V2

Supplier: United States Biological
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Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ENZYME REGULATION: Inhibited by N-ethylmaleimide. Cellular Localization: Cytoplasm (Probable). Alternative Products: 5 named isoforms produced by alternative splicing. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2298-74V2
Reactivities: Human, Rat
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
P type: Pab
Purity: Serum
Alternative names: Cysteine protease ATG4B, Autophagy-related protein 4 homolog B, hAPG4B, Autophagin-1, Autophagy-related cysteine endopeptidase 1, AUT-like 1 cysteine endopeptidase, ATG4B, APG4B, AUTL1, KIAA0943
References: 1. Marino G, et al. J. Biol. Chem. 278:3671-3678(2003). ; 2. Kabeya Y, et al. J. Cell Sci. 117:2805-2812(2004). ; 3. Nagase T, et al. DNA Res. 6:63-70(1999). ; 4. Ota T, et al. Nat. Genet. 36:40-45(2004). ; 5. Sugawara K, et al. J. Biol. Chem. 280:40058-40065(2005). ; 6. Kumanomidou T, et al. J. Mol. Biol. 355:612-618(2006). ;
Additional info: TISSUE SPECIFICITY: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. SIMILARITY: Belongs to the peptidase C54 family. Species Crossreactivity: Human, rat. Other species not yet tested.

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