Home  >  Products  >  Atg4C (Apg4c, Autl3, Cysteine Protease ATG4C, Autophagy-related Protein 4 Homolog C, Autophagin-3, Autophagy-related Cysteine Endopeptidase 3, AUT-like 3 Cysteine Endopeptidase)
Atg4C (Apg4c, Autl3, Cysteine Protease ATG4C, Autophagy-related Protein 4 Homolog C, Autophagin-3, Autophagy-related Cysteine Endopeptidase 3, AUT-like 3 Cysteine Endopeptidase)

Atg4C (Apg4c, Autl3, Cysteine Protease ATG4C, Autophagy-related Protein 4 Homolog C, Autophagin-3, Autophagy-related Cysteine Endopeptidase 3, AUT-like 3 Cysteine Endopeptidase)

Cat no: A2298-74V4

Supplier: United States Biological
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Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. ENZYME REGULATION: Inhibited by N-ethylmaleimide. Cellular Localization: Cytoplasm (Probable). Tissue Specificity: Highly expressed in skeletal muscle, heart, liver and testis. Belongs to the peptidase C54 family. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: A2298-74V4
Reactivities: Human, Rat
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
P type: Pab
Purity: Serum
Alternative names: Autophagin-3, Autophagy-related cysteine endopeptidase 3, AUT-like 3 cysteine endopeptidase
References: 1. Marino G, et al. J. Biol. Chem. 278:3671-3678(2003). ; 2. Ota T, et al. Nat. Genet. 36:40-45(2004).
Additional info: Recognizes human ATG4C. Species Crossreactivity: rat. CAUTION: Please see the accession, sequence differs from that shown due to a frameshift in position 420. Other species not yet tested.

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