Home  >  Products  >  Atg7, Recombinant, Mouse, aa450-698, His-tag (Ubiquitin-like Modifier-activating Enzyme ATG7, ATG12-activating Enzyme E1 ATG7, Autophagy-related Protein 7, APG7-like, mAGP7, Ubiquitin-activating Enzyme E1-like Protein, Apg7l, 1810013K23Rik)
Atg7, Recombinant, Mouse, aa450-698, His-tag (Ubiquitin-like Modifier-activating Enzyme ATG7, ATG12-activating Enzyme E1 ATG7, Autophagy-related Protein 7, APG7-like, mAGP7, Ubiquitin-activating Enzyme E1-like Protein, Apg7l, 1810013K23Rik)

Atg7, Recombinant, Mouse, aa450-698, His-tag (Ubiquitin-like Modifier-activating Enzyme ATG7, ATG12-activating Enzyme E1 ATG7, Autophagy-related Protein 7, APG7-like, mAGP7, Ubiquitin-activating Enzyme E1-like Protein, Apg7l, 1810013K23Rik)

Cat no: 149785

Supplier: United States Biological
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Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog. In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death. Source: Recombinant protein corresponding to mouse ATG7, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~30kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 149785
Size: 50ug
Form: Supplied as a liquid in 1X PBS, 10% glycerol.
Purity: ~95%
References: 1. Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004; 23:2891-906. 2. Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5. 3. Kamada Y, Funakoshi T, Shintani T, et al. Tor-mediated induction of autophagy via Apg1 protein kinase complex. J. Cell. Biol. 2000; 150:1507-13. 4. Mizushima N, Noda T, Yoshimori T, et al. A protein conjugation system essential for autophagy. Nature 1998; 395: 395-8.

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