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ATIC mAb

ATIC mAb

Cat no: MB0029


Supplier: Bioworld Technology, Inc.
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The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine.
Catalogue number: MB0029
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P31939
Dilutions: WB: 1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human ATIC.
Species: This antibody detects endogenous levels of ATIC and does not cross-react with related proteins
Molecular weight: Predicted band size:64KDa Observed band size:64KDa
Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase2.IMP cyclohydrolase; ATIC; IMP synthase Inosinicase; PURH; AICAR; AICARFT; IMPCHASE
Additional info: For research use only, not for use in diagnostic procedure.

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