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ATNX1 (ATX1, Ataxin 1, Ataxin-1, Spinocerebellar Ataxia Type 1 Protein, ATX1, SCA1)

ATNX1 (ATX1, Ataxin 1, Ataxin-1, Spinocerebellar Ataxia Type 1 Protein, ATX1, SCA1)

Cat no: A4159-04D

Supplier: United States Biological
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The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. Applications: Suitable for use in ELISA. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:64,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A4159-04D
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1), olivopontocerebellar ataxia 1, autosomal dominant, OTTHUMP00000039306, OTTHUMP00000016065, SCA1, D6S504E, ATX1, ataxin 1, ATXN1
References: 1. Banfi S, Servadio A, Chung MY, Kwiatkowski TJ Jr, McCall AE, Duvick LA, Shen Y, Roth EJ, Orr HT, Zoghbi HY Identification and characterization of the gene causing type 1 spinocerebellar ataxia Nat. Genet. 1994 Aug 7 (4): 513-20
Additional info: Recognizes ATXN1. Species sequence homology: human, canine, porcine.

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