Home  >  Products  >  ATP-Citrate Lyase, phosphorylated (Ser455) (ACL, ATP Citrate (pro-S) Lyase, ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8)
ATP-Citrate Lyase, phosphorylated (Ser455) (ACL, ATP Citrate (pro-S) Lyase, ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8)

ATP-Citrate Lyase, phosphorylated (Ser455) (ACL, ATP Citrate (pro-S) Lyase, ATP Citrate Synthase, Citrate Cleavage Enzyme, EC 2.3.3.8)

Cat no: A4001-35C

Supplier: United States Biological
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ATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACL and insulin to increase phosphorylation of ACL (2). Applications: Suitable for use in Western Blotting, Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Immunoprecipitation: 1:20 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: A4001-35C
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Elshourbagy et al. Europ. J. Biochem. 204: 491-499, 1992. 2. Benjamin, W. B., and Singer, I. (1974) Biochim. Biophys. Acta 251, 28-422.
Additional info: Recognizes human ATP-Citrate Lyase when phosphorylated at Ser455.

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